Drug interactions
Arformoterol + Digoxin
Severity: Moderate
Arformoterol and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arformoterol can lower serum potassium and may provoke tachyarrhythmias, which increases susceptibility to digoxin toxicity. The risk is greater with higher doses and in patients with hypoxia or heart disease.
What this interaction means in plain words
Arformoterol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Digoxin belongs to Cardiovascular.
Why it happens
Beta-2 agonist-driven cellular potassium uptake causes hypokalemia, enhancing digoxin arrhythmogenicity.
What to do
Monitor serum potassium and ECG, and correct hypokalemia. Watch for digoxin toxicity symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Digoxin?
MediHelp rates the interaction as moderate. Arformoterol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Arformoterol can lower serum potassium and may provoke tachyarrhythmias, which increases susceptibility to digoxin toxicity. The risk is greater with higher doses and in patients with hypoxia or heart disease.
How serious is the interaction between Arformoterol and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG, and correct hypokalemia. Watch for digoxin toxicity symptoms.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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