Drug interactions
Arformoterol + Fluconazole
Severity: Moderate
Arformoterol and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can prolong the QT interval and long-acting beta-agonists such as arformoterol may also affect QTc and cause hypokalemia. Used together, they may add to the risk of ventricular arrhythmia, especially in patients with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Arformoterol and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Fluconazole belongs to Anti Fungals.
Why it happens
Additive pharmacodynamic QT prolongation, with beta-agonist-induced hypokalemia potentially increasing arrhythmic susceptibility.
What to do
Check potassium and magnesium and correct deficits. Monitor ECG and for palpitations in patients with cardiac risk factors or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Fluconazole?
MediHelp rates the interaction as moderate. Arformoterol and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can prolong the QT interval and long-acting beta-agonists such as arformoterol may also affect QTc and cause hypokalemia. Used together, they may add to the risk of ventricular arrhythmia, especially in patients with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Arformoterol and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and correct deficits. Monitor ECG and for palpitations in patients with cardiac risk factors or other QT-prolonging drugs.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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