Drug interactions
Arformoterol + Ondansetron
Severity: Moderate
Arformoterol and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arformoterol, a long-acting beta-agonist, can prolong QTc, cause tachycardia and lower potassium, and ondansetron also prolongs QTc. The combination may raise the risk of ventricular arrhythmias in susceptible patients.
What this interaction means in plain words
Arformoterol and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia and tachycardia.
What to do
Monitor ECG and potassium in patients with cardiac disease or other QT risk factors. Use a single IV ondansetron dose or an alternative antiemetic if risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Ondansetron?
MediHelp rates the interaction as moderate. Arformoterol and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Arformoterol, a long-acting beta-agonist, can prolong QTc, cause tachycardia and lower potassium, and ondansetron also prolongs QTc. The combination may raise the risk of ventricular arrhythmias in susceptible patients.
How serious is the interaction between Arformoterol and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and potassium in patients with cardiac disease or other QT risk factors. Use a single IV ondansetron dose or an alternative antiemetic if risk is high.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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