Drug interactions
Arformoterol + Ranolazine
Severity: Moderate
Arformoterol and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine prolongs QTc, and long-acting beta-agonists like arformoterol can cause tachycardia, hypokalemia and QT prolongation. The combination may increase the risk of ventricular arrhythmias, particularly in patients with cardiac disease.
What this interaction means in plain words
Arformoterol and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Ranolazine belongs to Cardiovascular.
Why it happens
Additive QT prolongation, with beta-agonist induced hypokalemia contributing.
What to do
Monitor ECG and serum potassium, especially in patients with heart disease or electrolyte disturbance. Correct hypokalemia before and during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Ranolazine?
MediHelp rates the interaction as moderate. Arformoterol and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine prolongs QTc, and long-acting beta-agonists like arformoterol can cause tachycardia, hypokalemia and QT prolongation. The combination may increase the risk of ventricular arrhythmias, particularly in patients with cardiac disease.
How serious is the interaction between Arformoterol and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium, especially in patients with heart disease or electrolyte disturbance. Correct hypokalemia before and during therapy.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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