Drug interactions
Arformoterol + Sevoflurane
Severity: Moderate
Arformoterol and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane can prolong the QT interval, and arformoterol, a long-acting beta-2 agonist, may cause tachycardia, hypokalemia and QT prolongation. The combination may modestly raise arrhythmia risk during anesthesia.
What this interaction means in plain words
Arformoterol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization and beta-2 agonist induced hypokalemia and tachycardia.
What to do
Check potassium and obtain an ECG in patients with cardiac risk factors before anesthesia. Monitor ECG intraoperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Sevoflurane?
MediHelp rates the interaction as moderate. Arformoterol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane can prolong the QT interval, and arformoterol, a long-acting beta-2 agonist, may cause tachycardia, hypokalemia and QT prolongation. The combination may modestly raise arrhythmia risk during anesthesia.
How serious is the interaction between Arformoterol and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and obtain an ECG in patients with cardiac risk factors before anesthesia. Monitor ECG intraoperatively.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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