Drug interactions
Arformoterol + Sotalol
Severity: Major
Arformoterol and Sotalol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol blocks beta-2 receptors and can reduce arformoterol's bronchodilator effect or provoke bronchospasm. Arformoterol may also lower potassium and prolong QT, increasing torsades risk with sotalol.
What this interaction means in plain words
Arformoterol and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arformoterol belongs to Respiratory; Sotalol belongs to Cardiovascular.
Why it happens
Beta-2 antagonism opposes the agonist, while beta-agonist induced hypokalemia and QT effects add to sotalol's QT prolongation.
What to do
Avoid the combination if possible and choose an alternative to sotalol in patients with obstructive lung disease; if used together, monitor potassium, QTc and respiratory function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Arformoterol and Sotalol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Sotalol?
MediHelp rates the interaction as major. Arformoterol and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotalol blocks beta-2 receptors and can reduce arformoterol's bronchodilator effect or provoke bronchospasm. Arformoterol may also lower potassium and prolong QT, increasing torsades risk with sotalol.
How serious is the interaction between Arformoterol and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and choose an alternative to sotalol in patients with obstructive lung disease; if used together, monitor potassium, QTc and respiratory function.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
