Drug interactions
Argatroban + Azathioprine
Severity: Minor
Argatroban and Azathioprine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No well-established interaction exists between azathioprine and argatroban. Azathioprine is known to reduce the anticoagulant effect of warfarin, but this has not been shown for argatroban, a direct thrombin inhibitor.
What this interaction means in plain words
Argatroban and Azathioprine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Argatroban belongs to Cardiovascular; Azathioprine belongs to Gastrointestinal Tract.
Why it happens
No established mechanism; the effect on warfarin does not extend to direct thrombin inhibitors.
What to do
No specific action needed; monitor aPTT as usual during argatroban therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Azathioprine?
MediHelp rates the interaction as minor. Argatroban and Azathioprine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No well-established interaction exists between azathioprine and argatroban. Azathioprine is known to reduce the anticoagulant effect of warfarin, but this has not been shown for argatroban, a direct thrombin inhibitor.
How serious is the interaction between Argatroban and Azathioprine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action needed; monitor aPTT as usual during argatroban therapy.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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