Drug interactions
Argatroban + Cefazolin
Severity: Minor
Argatroban and Cefazolin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefazolin has little effect on coagulation, so a meaningful interaction with argatroban is not well established. Any added bleeding risk is theoretical.
What this interaction means in plain words
Argatroban and Cefazolin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Argatroban belongs to Cardiovascular; Cefazolin belongs to Anti Bacterial.
Why it happens
No established mechanism; a theoretical additive effect on hemostasis.
What to do
No specific action beyond routine aPTT monitoring of argatroban therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefazolin
- Amikacin + Cefazolin Moderate
- Bcg vaccine live + Cefazolin Moderate
- Cefazolin + Cholera vaccine Moderate
- Cefazolin + Dexamethasone-tobramycin Moderate
- Cefazolin + Gentamicin Moderate
- Cefazolin + Kanamycin Moderate
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Cefazolin?
MediHelp rates the interaction as minor. Argatroban and Cefazolin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefazolin has little effect on coagulation, so a meaningful interaction with argatroban is not well established. Any added bleeding risk is theoretical.
How serious is the interaction between Argatroban and Cefazolin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action beyond routine aPTT monitoring of argatroban therapy.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefazolin page.
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