Drug interactions
Argatroban + Cefoxitin
Severity: Minor
Argatroban and Cefoxitin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefoxitin lacks the thiotetrazole side chain linked to hypoprothrombinemia, so a relevant additive effect with argatroban is unlikely. Argatroban itself prolongs the INR, which can confound monitoring in patients on antibiotics. The concern is largely theoretical.
What this interaction means in plain words
Argatroban and Cefoxitin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Argatroban belongs to Cardiovascular; Cefoxitin belongs to Anti Bacterial.
Why it happens
Theoretical additive effect on coagulation; no established mechanism for cefoxitin.
What to do
Titrate argatroban to aPTT and monitor for bleeding; no cefoxitin-specific change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefoxitin
- Amikacin + Cefoxitin Moderate
- Aztreonam + Cefoxitin Moderate
- Bcg vaccine live + Cefoxitin Moderate
- Cefoxitin + Chloramphenicol Moderate
- Cefoxitin + Cholera vaccine Moderate
- Cefoxitin + Dexamethasone-tobramycin Moderate
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Cefoxitin?
MediHelp rates the interaction as minor. Argatroban and Cefoxitin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefoxitin lacks the thiotetrazole side chain linked to hypoprothrombinemia, so a relevant additive effect with argatroban is unlikely. Argatroban itself prolongs the INR, which can confound monitoring in patients on antibiotics. The concern is largely theoretical.
How serious is the interaction between Argatroban and Cefoxitin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate argatroban to aPTT and monitor for bleeding; no cefoxitin-specific change is required.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Aztreonam, Bcg vaccine live. The full list is on the Cefoxitin page.
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