Drug interactions
Argatroban + Celecoxib
Severity: Moderate
Argatroban and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib adds to bleeding risk when given with a direct thrombin inhibitor, mainly through antiplatelet effects and gastric mucosal injury. Gastrointestinal bleeding is the main concern.
What this interaction means in plain words
Argatroban and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Celecoxib belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment: argatroban inhibits thrombin while NSAIDs impair platelet function and damage GI mucosa.
What to do
Monitor for signs of bleeding and the aPTT or hemoglobin as appropriate. Prefer acetaminophen for analgesia when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Celecoxib?
MediHelp rates the interaction as moderate. Argatroban and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib adds to bleeding risk when given with a direct thrombin inhibitor, mainly through antiplatelet effects and gastric mucosal injury. Gastrointestinal bleeding is the main concern.
How serious is the interaction between Argatroban and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and the aPTT or hemoglobin as appropriate. Prefer acetaminophen for analgesia when possible.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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