Drug interactions
Argatroban + Etodolac
Severity: Moderate
Argatroban and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac impairs platelet function and can injure the gastric mucosa, so together with argatroban there is a higher risk of bleeding. Severity depends on the patient's bleeding risk.
What this interaction means in plain words
Argatroban and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment: NSAID platelet inhibition combined with direct thrombin inhibition.
What to do
Avoid unnecessary NSAID use during argatroban therapy; if used, monitor aPTT, hemoglobin and for signs of bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Argatroban and Etodolac, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Etodolac?
MediHelp rates the interaction as moderate. Argatroban and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etodolac impairs platelet function and can injure the gastric mucosa, so together with argatroban there is a higher risk of bleeding. Severity depends on the patient's bleeding risk.
How serious is the interaction between Argatroban and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary NSAID use during argatroban therapy; if used, monitor aPTT, hemoglobin and for signs of bleeding.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
