Drug interactions
Argatroban + Imatinib
Severity: Moderate
Argatroban and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can cause thrombocytopenia and other cytopenias, and argatroban is a direct thrombin inhibitor that raises bleeding risk. Used together they may increase the likelihood of clinically significant hemorrhage.
What this interaction means in plain words
Argatroban and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Imatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic effect: imatinib-related thrombocytopenia combined with anticoagulant activity of argatroban.
What to do
Monitor platelet counts and aPTT and watch for bleeding signs during co-therapy. Adjust argatroban dosing to aPTT and hold anticoagulation if platelets fall significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Imatinib?
MediHelp rates the interaction as moderate. Argatroban and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can cause thrombocytopenia and other cytopenias, and argatroban is a direct thrombin inhibitor that raises bleeding risk. Used together they may increase the likelihood of clinically significant hemorrhage.
How serious is the interaction between Argatroban and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and aPTT and watch for bleeding signs during co-therapy. Adjust argatroban dosing to aPTT and hold anticoagulation if platelets fall significantly.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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