Drug interactions
Argatroban + Indomethacin
Severity: Major
Argatroban and Indomethacin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin inhibits platelet function and can injure the gastric mucosa, which increases the bleeding risk in patients on the direct thrombin inhibitor argatroban. Serious gastrointestinal or other hemorrhage may occur.
What this interaction means in plain words
Argatroban and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Argatroban belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment: antiplatelet effect of NSAID plus thrombin inhibition, along with NSAID gastric mucosal damage.
What to do
Avoid NSAIDs during argatroban therapy where possible; if unavoidable, monitor aPTT and watch for bleeding, considering gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Indomethacin?
MediHelp rates the interaction as major. Argatroban and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indomethacin inhibits platelet function and can injure the gastric mucosa, which increases the bleeding risk in patients on the direct thrombin inhibitor argatroban. Serious gastrointestinal or other hemorrhage may occur.
How serious is the interaction between Argatroban and Indomethacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs during argatroban therapy where possible; if unavoidable, monitor aPTT and watch for bleeding, considering gastroprotection.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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