Drug interactions
Argatroban + Ketoprofen
Severity: Major
Argatroban and Ketoprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining ketoprofen with argatroban increases the risk of bleeding, including gastrointestinal hemorrhage, because of impaired platelet function and mucosal injury. Bleeding may be serious in patients receiving full anticoagulation.
What this interaction means in plain words
Argatroban and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Argatroban belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effect: direct thrombin inhibition plus NSAID inhibition of platelet aggregation and gastric mucosal damage.
What to do
Avoid NSAIDs where possible and use paracetamol instead; if combined, monitor for bleeding signs and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Ketoprofen?
MediHelp rates the interaction as major. Argatroban and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining ketoprofen with argatroban increases the risk of bleeding, including gastrointestinal hemorrhage, because of impaired platelet function and mucosal injury. Bleeding may be serious in patients receiving full anticoagulation.
How serious is the interaction between Argatroban and Ketoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible and use paracetamol instead; if combined, monitor for bleeding signs and hemoglobin.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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