Drug interactions
Argatroban + Levothyroxine
Severity: Minor
Argatroban and Levothyroxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone can increase catabolism of vitamin K-dependent clotting factors, and this enhances the effect of oral anticoagulants. For argatroban, a direct thrombin inhibitor, any such effect is not well established, so the interaction is largely theoretical.
What this interaction means in plain words
Argatroban and Levothyroxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Argatroban belongs to Cardiovascular; Levothyroxine belongs to Endocrine.
Why it happens
Possible additive effect on coagulation; thyroid hormone increases clotting factor turnover, but a clear interaction with direct thrombin inhibitors is not established.
What to do
No routine change is needed; monitor aPTT per argatroban protocol when thyroid dose changes or in newly treated thyrotoxic patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Argatroban and Levothyroxine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Levothyroxine
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Levothyroxine?
MediHelp rates the interaction as minor. Argatroban and Levothyroxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thyroid hormone can increase catabolism of vitamin K-dependent clotting factors, and this enhances the effect of oral anticoagulants. For argatroban, a direct thrombin inhibitor, any such effect is not well established, so the interaction is largely theoretical.
How serious is the interaction between Argatroban and Levothyroxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor aPTT per argatroban protocol when thyroid dose changes or in newly treated thyrotoxic patients.
What other medicines interact with Levothyroxine?
MediHelp also lists interactions of Levothyroxine with, for example, Cholestyramine, Sodium iodide i-131, Tiratricol. The full list is on the Levothyroxine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
