Drug interactions
Argatroban + Prednisone
Severity: Moderate
Argatroban and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids may modestly alter coagulation and can increase bleeding risk through GI mucosal injury and vascular fragility. Argatroban is a direct thrombin inhibitor, so any effect on anticoagulation is unpredictable.
What this interaction means in plain words
Argatroban and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Prednisone belongs to Endocrine.
Why it happens
Not well established; combined effects on coagulation and mucosal or vascular integrity.
What to do
Monitor aPTT per argatroban protocol and watch for signs of bleeding, especially gastrointestinal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Prednisone?
MediHelp rates the interaction as moderate. Argatroban and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids may modestly alter coagulation and can increase bleeding risk through GI mucosal injury and vascular fragility. Argatroban is a direct thrombin inhibitor, so any effect on anticoagulation is unpredictable.
How serious is the interaction between Argatroban and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT per argatroban protocol and watch for signs of bleeding, especially gastrointestinal.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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