Drug interactions
Argatroban + Secobarbital
Severity: Minor
Argatroban and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Argatroban is cleared mainly by hepatic metabolism, with CYP3A4/5 playing a minor role. A clinically important reduction in anticoagulant effect from secobarbital induction is not well established.
What this interaction means in plain words
Argatroban and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Argatroban belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate enzyme induction might slightly increase argatroban clearance, but the contribution of CYP3A4 is minor.
What to do
No dose change needed; continue routine aPTT monitoring during argatroban therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Secobarbital?
MediHelp rates the interaction as minor. Argatroban and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Argatroban is cleared mainly by hepatic metabolism, with CYP3A4/5 playing a minor role. A clinically important reduction in anticoagulant effect from secobarbital induction is not well established.
How serious is the interaction between Argatroban and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change needed; continue routine aPTT monitoring during argatroban therapy.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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