Drug interactions
Argatroban + Ticagrelor
Severity: Moderate
Argatroban and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Argatroban is a direct thrombin inhibitor, and adding ticagrelor raises the risk of bleeding through combined anticoagulant and antiplatelet effects.
What this interaction means in plain words
Argatroban and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Ticagrelor belongs to Cardiovascular.
Why it happens
Additive hemostatic impairment: direct thrombin inhibition plus P2Y12 receptor blockade.
What to do
Monitor aPTT per argatroban protocol and observe for bleeding. Keep the duration of combined therapy as short as clinically possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Ticagrelor?
MediHelp rates the interaction as moderate. Argatroban and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Argatroban is a direct thrombin inhibitor, and adding ticagrelor raises the risk of bleeding through combined anticoagulant and antiplatelet effects.
How serious is the interaction between Argatroban and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT per argatroban protocol and observe for bleeding. Keep the duration of combined therapy as short as clinically possible.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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