Drug interactions
Argatroban + Tolfenamic acid
Severity: Moderate
Argatroban and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolfenamic acid is an NSAID that inhibits platelet function and can irritate the gastrointestinal mucosa. Combined with argatroban it increases the likelihood of bleeding.
What this interaction means in plain words
Argatroban and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment from thrombin inhibition and NSAID-induced platelet inhibition and mucosal injury.
What to do
Prefer paracetamol for pain relief during argatroban therapy; if an NSAID is needed, monitor for bleeding and hemoglobin and aPTT.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Argatroban with Tolfenamic acid?
MediHelp rates the interaction as moderate. Argatroban and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolfenamic acid is an NSAID that inhibits platelet function and can irritate the gastrointestinal mucosa. Combined with argatroban it increases the likelihood of bleeding.
How serious is the interaction between Argatroban and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol for pain relief during argatroban therapy; if an NSAID is needed, monitor for bleeding and hemoglobin and aPTT.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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