Drug interactions
Aripiprazole + Atropine
Severity: Minor
Aripiprazole and Atropine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole has weak anticholinergic activity, so any additive effect with atropine is small. Systemic atropine may cause dry mouth, tachycardia, urinary retention and confusion, which may be slightly more pronounced in susceptible patients.
What this interaction means in plain words
Aripiprazole and Atropine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Atropine belongs to Miscellaneous.
Why it happens
Possible modest additive antimuscarinic effects.
What to do
No routine adjustment is needed; monitor for anticholinergic effects such as confusion, constipation and urinary retention, especially in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Aripiprazole with Atropine?
MediHelp rates the interaction as minor. Aripiprazole and Atropine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aripiprazole has weak anticholinergic activity, so any additive effect with atropine is small. Systemic atropine may cause dry mouth, tachycardia, urinary retention and confusion, which may be slightly more pronounced in susceptible patients.
How serious is the interaction between Aripiprazole and Atropine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for anticholinergic effects such as confusion, constipation and urinary retention, especially in older patients.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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