Drug interactions
Aripiprazole + Azelastine-fluticasone
Severity: Minor
Aripiprazole and Azelastine-fluticasone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine nasal spray can cause drowsiness in some patients, and aripiprazole is also sedating. Together they may cause more daytime sleepiness and impaired alertness, although systemic azelastine exposure from the nasal spray is modest.
What this interaction means in plain words
Aripiprazole and Azelastine-fluticasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Azelastine-fluticasone belongs to Respiratory.
Why it happens
Additive central nervous system depression through antihistaminic and antipsychotic effects.
What to do
Advise patients to see how they respond before driving or operating machinery. Reduce or stop azelastine if troublesome sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Azelastine-fluticasone?
MediHelp rates the interaction as minor. Aripiprazole and Azelastine-fluticasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azelastine nasal spray can cause drowsiness in some patients, and aripiprazole is also sedating. Together they may cause more daytime sleepiness and impaired alertness, although systemic azelastine exposure from the nasal spray is modest.
How serious is the interaction between Aripiprazole and Azelastine-fluticasone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to see how they respond before driving or operating machinery. Reduce or stop azelastine if troublesome sedation occurs.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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