Drug interactions
Aripiprazole + Brompheniramine
Severity: Moderate
Aripiprazole and Brompheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine and can add to the drowsiness and impaired psychomotor performance seen with aripiprazole. Anticholinergic effects may also be additive.
What this interaction means in plain words
Aripiprazole and Brompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Brompheniramine belongs to Respiratory.
Why it happens
Additive CNS depression via histamine H1 blockade and antipsychotic receptor effects.
What to do
Warn patients about sedation and impaired driving; use a non-sedating antihistamine where an antihistamine is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Brompheniramine
Frequently asked questions
Can I take Aripiprazole with Brompheniramine?
MediHelp rates the interaction as moderate. Aripiprazole and Brompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine and can add to the drowsiness and impaired psychomotor performance seen with aripiprazole. Anticholinergic effects may also be additive.
How serious is the interaction between Aripiprazole and Brompheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about sedation and impaired driving; use a non-sedating antihistamine where an antihistamine is needed.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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