Drug interactions
Aripiprazole + Carbinoxamine
Severity: Minor
Aripiprazole and Carbinoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating first-generation antihistamine with anticholinergic activity. Combined with aripiprazole it can increase drowsiness, impair psychomotor performance and add to anticholinergic effects.
What this interaction means in plain words
Aripiprazole and Carbinoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Carbinoxamine belongs to Respiratory.
Why it happens
Additive CNS depression from H1 antihistamine and antipsychotic effects.
What to do
Warn patients about drowsiness and avoid driving until response is known; consider a non-sedating antihistamine if sedation is troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Aripiprazole with Carbinoxamine?
MediHelp rates the interaction as minor. Aripiprazole and Carbinoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbinoxamine is a sedating first-generation antihistamine with anticholinergic activity. Combined with aripiprazole it can increase drowsiness, impair psychomotor performance and add to anticholinergic effects.
How serious is the interaction between Aripiprazole and Carbinoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about drowsiness and avoid driving until response is known; consider a non-sedating antihistamine if sedation is troublesome.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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