Drug interactions
Aripiprazole + Cariprazine
Severity: Moderate
Aripiprazole and Cariprazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are dopamine D2/D3 partial agonist antipsychotics, so combining them duplicates therapy. This raises the risk of akathisia, extrapyramidal symptoms, sedation and orthostasis without proven additional benefit.
What this interaction means in plain words
Aripiprazole and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Cariprazine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects at dopamine and serotonin receptors.
What to do
Avoid concurrent use except during a short, planned cross-titration, and monitor for akathisia, sedation and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Cariprazine
Frequently asked questions
Can I take Aripiprazole with Cariprazine?
MediHelp rates the interaction as moderate. Aripiprazole and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are dopamine D2/D3 partial agonist antipsychotics, so combining them duplicates therapy. This raises the risk of akathisia, extrapyramidal symptoms, sedation and orthostasis without proven additional benefit.
How serious is the interaction between Aripiprazole and Cariprazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use except during a short, planned cross-titration, and monitor for akathisia, sedation and blood pressure.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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