Drug interactions
Aripiprazole + Chloramphenicol
Severity: Moderate
Aripiprazole and Chloramphenicol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may raise aripiprazole exposure by inhibiting its metabolism, increasing sedation, akathisia, orthostasis and other adverse effects. The magnitude is uncertain, as chloramphenicol is a weaker CYP inhibitor than the azoles.
What this interaction means in plain words
Aripiprazole and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Chloramphenicol inhibits CYP3A4, which contributes to aripiprazole clearance.
What to do
Monitor for adverse effects and consider reducing the aripiprazole dose during co-therapy. Restore the dose after chloramphenicol is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Chloramphenicol?
MediHelp rates the interaction as moderate. Aripiprazole and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may raise aripiprazole exposure by inhibiting its metabolism, increasing sedation, akathisia, orthostasis and other adverse effects. The magnitude is uncertain, as chloramphenicol is a weaker CYP inhibitor than the azoles.
How serious is the interaction between Aripiprazole and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and consider reducing the aripiprazole dose during co-therapy. Restore the dose after chloramphenicol is discontinued.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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