Drug interactions
Aripiprazole + Chlorpheniramine
Severity: Moderate
Aripiprazole and Chlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine is a sedating antihistamine that can add to aripiprazole-related drowsiness and impair alertness. Anticholinergic effects may also be additive.
What this interaction means in plain words
Aripiprazole and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Chlorpheniramine belongs to Respiratory.
Why it happens
Additive CNS depression through H1 antagonism and antipsychotic effects.
What to do
Counsel on sedation and driving risk, and prefer a non-sedating antihistamine when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Aripiprazole with Chlorpheniramine?
MediHelp rates the interaction as moderate. Aripiprazole and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine is a sedating antihistamine that can add to aripiprazole-related drowsiness and impair alertness. Anticholinergic effects may also be additive.
How serious is the interaction between Aripiprazole and Chlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and driving risk, and prefer a non-sedating antihistamine when feasible.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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