Drug interactions
Aripiprazole + Cimetidine
Severity: Minor
Aripiprazole and Cimetidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine is a weak CYP3A4 and CYP2D6 inhibitor and may raise aripiprazole exposure slightly. Clinically significant effects are uncommon.
What this interaction means in plain words
Aripiprazole and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Cimetidine weakly inhibits CYP3A4 and CYP2D6 metabolism of aripiprazole.
What to do
No dose adjustment is usually needed; monitor for akathisia, sedation or other adverse effects after starting cimetidine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Cimetidine?
MediHelp rates the interaction as minor. Aripiprazole and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine is a weak CYP3A4 and CYP2D6 inhibitor and may raise aripiprazole exposure slightly. Clinically significant effects are uncommon.
How serious is the interaction between Aripiprazole and Cimetidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for akathisia, sedation or other adverse effects after starting cimetidine.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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