Drug interactions
Aripiprazole + Ciprofloxacin
Severity: Moderate
Aripiprazole and Ciprofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been associated with QT prolongation, although the effect of each is modest. Together they may increase arrhythmia risk in patients with additional risk factors. Ciprofloxacin may also modestly raise aripiprazole exposure through CYP inhibition.
What this interaction means in plain words
Aripiprazole and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Ciprofloxacin belongs to Anti Bacterial.
Why it happens
Additive effects on cardiac repolarization; ciprofloxacin may weakly inhibit aripiprazole metabolism.
What to do
Check for other QT risk factors and correct electrolyte disturbances; consider an ECG if risk factors are present. Monitor for aripiprazole adverse effects such as akathisia or sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Ciprofloxacin?
MediHelp rates the interaction as moderate. Aripiprazole and Ciprofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have been associated with QT prolongation, although the effect of each is modest. Together they may increase arrhythmia risk in patients with additional risk factors. Ciprofloxacin may also modestly raise aripiprazole exposure through CYP inhibition.
How serious is the interaction between Aripiprazole and Ciprofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check for other QT risk factors and correct electrolyte disturbances; consider an ECG if risk factors are present. Monitor for aripiprazole adverse effects such as akathisia or sedation.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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