Drug interactions
Aripiprazole + Cyclizine
Severity: Moderate
Aripiprazole and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine with anticholinergic activity and can add to aripiprazole sedation and anticholinergic effects. Its dopamine-related and antiemetic actions may also overlap with antipsychotic effects.
What this interaction means in plain words
Aripiprazole and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Cyclizine belongs to Respiratory.
Why it happens
Additive CNS depression and anticholinergic effects through H1 and muscarinic blockade.
What to do
Monitor for sedation, confusion, constipation and urinary retention, and use the lowest effective cyclizine dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Aripiprazole with Cyclizine?
MediHelp rates the interaction as moderate. Aripiprazole and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating antihistamine with anticholinergic activity and can add to aripiprazole sedation and anticholinergic effects. Its dopamine-related and antiemetic actions may also overlap with antipsychotic effects.
How serious is the interaction between Aripiprazole and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion, constipation and urinary retention, and use the lowest effective cyclizine dose for the shortest time.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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