Drug interactions
Aripiprazole + Dapagliflozin-metformin
Severity: Minor
Aripiprazole and Dapagliflozin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole can produce changes in glucose regulation, and in some patients hyperglycemia may develop. This may partly offset the glucose-lowering effect of the dapagliflozin-metformin combination in diabetic patients.
What this interaction means in plain words
Aripiprazole and Dapagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Dapagliflozin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, as atypical antipsychotics may impair insulin sensitivity and glucose metabolism.
What to do
Monitor fasting glucose and HbA1c after starting or changing aripiprazole, and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Dapagliflozin-metformin?
MediHelp rates the interaction as minor. Aripiprazole and Dapagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aripiprazole can produce changes in glucose regulation, and in some patients hyperglycemia may develop. This may partly offset the glucose-lowering effect of the dapagliflozin-metformin combination in diabetic patients.
How serious is the interaction between Aripiprazole and Dapagliflozin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting or changing aripiprazole, and adjust antidiabetic therapy if control worsens.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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