Drug interactions
Aripiprazole + Deutetrabenazine
Severity: Moderate
Aripiprazole and Deutetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on dopaminergic pathways: aripiprazole is a partial D2 agonist and deutetrabenazine depletes presynaptic monoamines. Together they may add to parkinsonism, akathisia, sedation and rarely neuroleptic malignant syndrome, and may have a small additive QT effect.
What this interaction means in plain words
Aripiprazole and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive antidopaminergic effects from D2 receptor modulation and VMAT2 inhibition, with additive sedation.
What to do
Monitor for extrapyramidal symptoms, akathisia, sedation, and depression, and use the lowest effective doses. Consider an ECG if other QT-prolonging drugs or risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Aripiprazole with Deutetrabenazine?
MediHelp rates the interaction as moderate. Aripiprazole and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on dopaminergic pathways: aripiprazole is a partial D2 agonist and deutetrabenazine depletes presynaptic monoamines. Together they may add to parkinsonism, akathisia, sedation and rarely neuroleptic malignant syndrome, and may have a small additive QT effect.
How serious is the interaction between Aripiprazole and Deutetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, akathisia, sedation, and depression, and use the lowest effective doses. Consider an ECG if other QT-prolonging drugs or risk factors are present.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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