Drug interactions
Aripiprazole + Doxepin
Severity: Moderate
Aripiprazole and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is sedating and is metabolized partly by CYP2D6 and CYP2C19, and both drugs can cause drowsiness and orthostatic hypotension. At higher doses doxepin may also prolong the QT interval, so additive cardiac effects are possible.
What this interaction means in plain words
Aripiprazole and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Doxepin belongs to Dermatology.
Why it happens
Additive sedative, hypotensive and QT-prolonging pharmacodynamic effects.
What to do
Monitor for sedation and orthostasis, and consider an ECG and electrolyte check if doxepin doses are high or other QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Aripiprazole with Doxepin?
MediHelp rates the interaction as moderate. Aripiprazole and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is sedating and is metabolized partly by CYP2D6 and CYP2C19, and both drugs can cause drowsiness and orthostatic hypotension. At higher doses doxepin may also prolong the QT interval, so additive cardiac effects are possible.
How serious is the interaction between Aripiprazole and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostasis, and consider an ECG and electrolyte check if doxepin doses are high or other QT-prolonging drugs are present.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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