Drug interactions
Aripiprazole + Fostemsavir
Severity: Moderate
Aripiprazole and Fostemsavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir has caused QTc prolongation at supratherapeutic doses, and aripiprazole has a small potential to affect QT interval. Combined use could add to QT risk, mainly in patients with other risk factors.
What this interaction means in plain words
Aripiprazole and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Fostemsavir belongs to Anti Virals.
Why it happens
Additive effects on cardiac repolarization.
What to do
Obtain a baseline ECG in patients with QT risk factors and correct potassium and magnesium abnormalities. Monitor ECG during concurrent use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Aripiprazole with Fostemsavir?
MediHelp rates the interaction as moderate. Aripiprazole and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir has caused QTc prolongation at supratherapeutic doses, and aripiprazole has a small potential to affect QT interval. Combined use could add to QT risk, mainly in patients with other risk factors.
How serious is the interaction between Aripiprazole and Fostemsavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with QT risk factors and correct potassium and magnesium abnormalities. Monitor ECG during concurrent use.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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