Drug interactions
Aripiprazole + Guanfacine
Severity: Moderate
Aripiprazole and Guanfacine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower blood pressure, so the combination can cause dizziness, orthostatic hypotension and syncope. Additive sedation is also possible.
What this interaction means in plain words
Aripiprazole and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Guanfacine belongs to Cardiovascular.
Why it happens
Additive hypotensive and sedative effects from central alpha-2 agonism and alpha-1 blockade.
What to do
Monitor blood pressure and heart rate, including standing readings, especially at start or dose changes. Advise rising slowly and adjust doses if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take Aripiprazole with Guanfacine?
MediHelp rates the interaction as moderate. Aripiprazole and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower blood pressure, so the combination can cause dizziness, orthostatic hypotension and syncope. Additive sedation is also possible.
How serious is the interaction between Aripiprazole and Guanfacine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, including standing readings, especially at start or dose changes. Advise rising slowly and adjust doses if symptomatic.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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