Drug interactions
Aripiprazole + Histrelin
Severity: Minor
Aripiprazole and Histrelin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, lowers testosterone, and androgen deprivation can prolong the QT interval. Aripiprazole may add a small effect, so combined use may modestly raise arrhythmia risk in predisposed patients.
What this interaction means in plain words
Aripiprazole and Histrelin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Histrelin belongs to Musculoskeletal.
Why it happens
Additive effects on cardiac repolarization.
What to do
Consider ECG monitoring in patients with other QT risk factors or heart disease. Correct electrolyte abnormalities.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Aripiprazole with Histrelin?
MediHelp rates the interaction as minor. Aripiprazole and Histrelin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Histrelin, a GnRH agonist, lowers testosterone, and androgen deprivation can prolong the QT interval. Aripiprazole may add a small effect, so combined use may modestly raise arrhythmia risk in predisposed patients.
How serious is the interaction between Aripiprazole and Histrelin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider ECG monitoring in patients with other QT risk factors or heart disease. Correct electrolyte abnormalities.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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