Drug interactions
Aripiprazole + Lenacapavir
Severity: Moderate
Aripiprazole and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor, and its long-acting injection may raise aripiprazole exposure for months after dosing. This may increase dose-related adverse effects of aripiprazole.
What this interaction means in plain words
Aripiprazole and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4-mediated aripiprazole metabolism.
What to do
Monitor for akathisia, sedation, orthostatic hypotension and extrapyramidal symptoms, and reduce the aripiprazole dose if they occur. Keep the prolonged inhibitory effect in mind after subcutaneous lenacapavir.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Aripiprazole with Lenacapavir?
MediHelp rates the interaction as moderate. Aripiprazole and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A4 inhibitor, and its long-acting injection may raise aripiprazole exposure for months after dosing. This may increase dose-related adverse effects of aripiprazole.
How serious is the interaction between Aripiprazole and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for akathisia, sedation, orthostatic hypotension and extrapyramidal symptoms, and reduce the aripiprazole dose if they occur. Keep the prolonged inhibitory effect in mind after subcutaneous lenacapavir.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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