Drug interactions
Aripiprazole + Levodopa
Severity: Moderate
Aripiprazole and Levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole blocks or partially agonizes dopamine D2 receptors, which can oppose the antiparkinsonian effect of levodopa. Motor symptoms in Parkinson's disease may worsen.
What this interaction means in plain words
Aripiprazole and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Levodopa belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Avoid aripiprazole in Parkinson's disease where possible. If an antipsychotic is needed, use quetiapine or clozapine at the lowest effective dose and monitor motor function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Aripiprazole with Levodopa?
MediHelp rates the interaction as moderate. Aripiprazole and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole blocks or partially agonizes dopamine D2 receptors, which can oppose the antiparkinsonian effect of levodopa. Motor symptoms in Parkinson's disease may worsen.
How serious is the interaction between Aripiprazole and Levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid aripiprazole in Parkinson's disease where possible. If an antipsychotic is needed, use quetiapine or clozapine at the lowest effective dose and monitor motor function.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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