Drug interactions
Aripiprazole + Levofloxacin
Severity: Minor
Aripiprazole and Levofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin can prolong the QTc interval, while aripiprazole has a low QT liability. Combined use carries a small added arrhythmia risk, mostly in patients with other risk factors.
What this interaction means in plain words
Aripiprazole and Levofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Levofloxacin belongs to Anti Bacterial.
Why it happens
Possible additive effects on cardiac repolarization, with aripiprazole contributing only weakly.
What to do
No routine action is needed in low-risk patients. Check an ECG and electrolytes if other QT-prolonging factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Levofloxacin?
MediHelp rates the interaction as minor. Aripiprazole and Levofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levofloxacin can prolong the QTc interval, while aripiprazole has a low QT liability. Combined use carries a small added arrhythmia risk, mostly in patients with other risk factors.
How serious is the interaction between Aripiprazole and Levofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed in low-risk patients. Check an ECG and electrolytes if other QT-prolonging factors are present.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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