Drug interactions
Aripiprazole + Linagliptin-metformin
Severity: Moderate
Aripiprazole and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole carries a relatively low but real risk of hyperglycemia and weight change, which can offset the glucose-lowering effect of metformin. Glycemic control may deteriorate in patients with diabetes.
What this interaction means in plain words
Aripiprazole and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Linagliptin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through antipsychotic-related changes in insulin resistance and glucose metabolism.
What to do
Monitor fasting glucose and HbA1c and weight after starting or adjusting aripiprazole, and intensify antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Aripiprazole and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole carries a relatively low but real risk of hyperglycemia and weight change, which can offset the glucose-lowering effect of metformin. Glycemic control may deteriorate in patients with diabetes.
How serious is the interaction between Aripiprazole and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c and weight after starting or adjusting aripiprazole, and intensify antidiabetic therapy if needed.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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