Drug interactions
Aripiprazole + Methohexital
Severity: Moderate
Aripiprazole and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a barbiturate anesthetic, and antipsychotics can add to its sedative and hypotensive effects. Recovery may be prolonged and cardiorespiratory depression more pronounced.
What this interaction means in plain words
Aripiprazole and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotensive effects.
What to do
Titrate methohexital carefully with continuous monitoring of blood pressure, oxygenation and ventilation. Be prepared to support the airway.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Methohexital
Frequently asked questions
Can I take Aripiprazole with Methohexital?
MediHelp rates the interaction as moderate. Aripiprazole and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a barbiturate anesthetic, and antipsychotics can add to its sedative and hypotensive effects. Recovery may be prolonged and cardiorespiratory depression more pronounced.
How serious is the interaction between Aripiprazole and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital carefully with continuous monitoring of blood pressure, oxygenation and ventilation. Be prepared to support the airway.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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