Drug interactions
Aripiprazole + Mifepristone
Severity: Major
Aripiprazole and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone is associated with QT prolongation, especially at the higher doses used for Cushing syndrome, and it also inhibits CYP3A4. Together these can raise aripiprazole exposure and add to arrhythmia risk.
What this interaction means in plain words
Aripiprazole and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Additive QTc prolongation plus CYP3A4 inhibition by mifepristone reducing aripiprazole clearance.
What to do
Avoid the combination where possible, particularly with chronic mifepristone dosing. If used together, obtain ECG and electrolytes and consider reducing the aripiprazole dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Aripiprazole with Mifepristone?
MediHelp rates the interaction as major. Aripiprazole and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone is associated with QT prolongation, especially at the higher doses used for Cushing syndrome, and it also inhibits CYP3A4. Together these can raise aripiprazole exposure and add to arrhythmia risk.
How serious is the interaction between Aripiprazole and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly with chronic mifepristone dosing. If used together, obtain ECG and electrolytes and consider reducing the aripiprazole dose.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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