Drug interactions
Aripiprazole + Naratriptan
Severity: Minor
Aripiprazole and Naratriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a triptan with an antipsychotic has a theoretical risk of serotonin toxicity, and serotonin modulators may also affect dopaminergic tone. Reports of clinically significant events with aripiprazole are rare.
What this interaction means in plain words
Aripiprazole and Naratriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic activity (5-HT1B/1D agonism with aripiprazole 5-HT1A partial agonism); not well established.
What to do
No routine change is needed; counsel the patient to report agitation, tremor, fever or muscle rigidity promptly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Aripiprazole with Naratriptan?
MediHelp rates the interaction as minor. Aripiprazole and Naratriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combining a triptan with an antipsychotic has a theoretical risk of serotonin toxicity, and serotonin modulators may also affect dopaminergic tone. Reports of clinically significant events with aripiprazole are rare.
How serious is the interaction between Aripiprazole and Naratriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; counsel the patient to report agitation, tremor, fever or muscle rigidity promptly.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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