Drug interactions
Aripiprazole + Orphenadrin
Severity: Moderate
Aripiprazole and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness, and orphenadrine adds anticholinergic effects. Concurrent use may increase sedation and impair alertness.
What this interaction means in plain words
Aripiprazole and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive CNS depressant and anticholinergic pharmacodynamic effects.
What to do
Monitor for excess sedation, confusion and anticholinergic symptoms, particularly in older patients. Reduce doses if impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Orphenadrin?
MediHelp rates the interaction as moderate. Aripiprazole and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and dizziness, and orphenadrine adds anticholinergic effects. Concurrent use may increase sedation and impair alertness.
How serious is the interaction between Aripiprazole and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, confusion and anticholinergic symptoms, particularly in older patients. Reduce doses if impairment develops.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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