Drug interactions
Aripiprazole + Primaquine
Severity: Moderate
Aripiprazole and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, and combining them may add to the risk of ventricular arrhythmia. The risk is higher with electrolyte disturbances or underlying heart disease. Aripiprazole has a relatively low QT liability so the overall risk is modest.
What this interaction means in plain words
Aripiprazole and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Primaquine belongs to Anti Parasitic.
Why it happens
Additive prolongation of cardiac repolarization (QTc) through pharmacodynamic effects.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat the ECG if other QT-prolonging drugs are added or if symptoms such as palpitations or syncope occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Primaquine?
MediHelp rates the interaction as moderate. Aripiprazole and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, and combining them may add to the risk of ventricular arrhythmia. The risk is higher with electrolyte disturbances or underlying heart disease. Aripiprazole has a relatively low QT liability so the overall risk is modest.
How serious is the interaction between Aripiprazole and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat the ECG if other QT-prolonging drugs are added or if symptoms such as palpitations or syncope occur.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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