Drug interactions
Aripiprazole + Procarbazine
Severity: Moderate
Aripiprazole and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak monoamine oxidase inhibiting activity, so combining it with an antipsychotic with serotonergic activity carries a theoretical risk of serotonin toxicity. It also adds to central nervous system depression. Documented cases with aripiprazole are lacking.
What this interaction means in plain words
Aripiprazole and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Weak MAO inhibition by procarbazine may add to serotonergic and dopaminergic effects of aripiprazole; the interaction is largely theoretical.
What to do
Monitor for agitation, tremor, hyperthermia, autonomic instability, and rigidity. Seek an alternative if features of serotonin toxicity or neuroleptic malignant syndrome appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Aripiprazole with Procarbazine?
MediHelp rates the interaction as moderate. Aripiprazole and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak monoamine oxidase inhibiting activity, so combining it with an antipsychotic with serotonergic activity carries a theoretical risk of serotonin toxicity. It also adds to central nervous system depression. Documented cases with aripiprazole are lacking.
How serious is the interaction between Aripiprazole and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, autonomic instability, and rigidity. Seek an alternative if features of serotonin toxicity or neuroleptic malignant syndrome appear.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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