Drug interactions
Aripiprazole + Propafenone
Severity: Moderate
Aripiprazole and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone is a CYP2D6 inhibitor and aripiprazole is cleared mainly by CYP2D6 and CYP3A4, so aripiprazole exposure can rise. Both agents also have some potential to affect cardiac conduction, although aripiprazole has a low QT liability.
What this interaction means in plain words
Aripiprazole and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Propafenone belongs to Cardiovascular.
Why it happens
Propafenone inhibits CYP2D6-mediated aripiprazole metabolism, with possible minor additive QT effects.
What to do
Monitor for aripiprazole adverse effects such as akathisia, sedation and orthostasis, and reduce the aripiprazole dose if needed (labeling advises about half the dose with strong CYP2D6 inhibitors). Obtain an ECG if other QT-prolonging risks are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Propafenone?
MediHelp rates the interaction as moderate. Aripiprazole and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone is a CYP2D6 inhibitor and aripiprazole is cleared mainly by CYP2D6 and CYP3A4, so aripiprazole exposure can rise. Both agents also have some potential to affect cardiac conduction, although aripiprazole has a low QT liability.
How serious is the interaction between Aripiprazole and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for aripiprazole adverse effects such as akathisia, sedation and orthostasis, and reduce the aripiprazole dose if needed (labeling advises about half the dose with strong CYP2D6 inhibitors). Obtain an ECG if other QT-prolonging risks are present.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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