Drug interactions
Aripiprazole + Rifapentine
Severity: Major
Aripiprazole and Rifapentine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP3A4 and can markedly lower aripiprazole concentrations, risking loss of antipsychotic or mood-stabilizing effect and relapse. The effect develops over days to weeks and persists after rifapentine is stopped.
What this interaction means in plain words
Aripiprazole and Rifapentine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Rifapentine belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4 increases the metabolism of aripiprazole.
What to do
Aripiprazole labeling advises roughly doubling the dose when combined with a strong CYP3A4 inducer, guided by clinical response. Reduce the dose back to baseline over 1 to 2 weeks after the inducer is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Aripiprazole with Rifapentine?
MediHelp rates the interaction as major. Aripiprazole and Rifapentine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifapentine induces CYP3A4 and can markedly lower aripiprazole concentrations, risking loss of antipsychotic or mood-stabilizing effect and relapse. The effect develops over days to weeks and persists after rifapentine is stopped.
How serious is the interaction between Aripiprazole and Rifapentine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Aripiprazole labeling advises roughly doubling the dose when combined with a strong CYP3A4 inducer, guided by clinical response. Reduce the dose back to baseline over 1 to 2 weeks after the inducer is stopped.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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