Drug interactions
Aripiprazole + Saxagliptin-metformin
Severity: Moderate
Aripiprazole and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole and other atypical antipsychotics can raise blood glucose and worsen glycemic control. This may reduce the effectiveness of saxagliptin-metformin in patients with diabetes. The effect varies between patients and is generally modest with aripiprazole.
What this interaction means in plain words
Aripiprazole and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through antipsychotic-associated metabolic effects and impaired glucose regulation.
What to do
Monitor fasting glucose and HbA1c when aripiprazole is started or changed. Adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Aripiprazole and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole and other atypical antipsychotics can raise blood glucose and worsen glycemic control. This may reduce the effectiveness of saxagliptin-metformin in patients with diabetes. The effect varies between patients and is generally modest with aripiprazole.
How serious is the interaction between Aripiprazole and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c when aripiprazole is started or changed. Adjust antidiabetic therapy as needed.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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