Drug interactions
Aripiprazole + Tiotropium
Severity: Minor
Aripiprazole and Tiotropium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole has weak anticholinergic activity, so additive antimuscarinic effects with tiotropium are possible but usually modest. No meaningful reduction in aripiprazole absorption is expected from inhaled tiotropium.
What this interaction means in plain words
Aripiprazole and Tiotropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Tiotropium belongs to Respiratory.
Why it happens
Weak additive antimuscarinic effects; systemic exposure to inhaled tiotropium is low.
What to do
No routine change is needed. Watch for dry mouth, constipation or urinary hesitancy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tiotropium
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Tiotropium?
MediHelp rates the interaction as minor. Aripiprazole and Tiotropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aripiprazole has weak anticholinergic activity, so additive antimuscarinic effects with tiotropium are possible but usually modest. No meaningful reduction in aripiprazole absorption is expected from inhaled tiotropium.
How serious is the interaction between Aripiprazole and Tiotropium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Watch for dry mouth, constipation or urinary hesitancy.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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