Drug interactions
Aripiprazole + Tranylcypromine
Severity: Moderate
Aripiprazole and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an MAO inhibitor with aripiprazole can occasionally cause serotonin toxicity because aripiprazole has serotonergic receptor activity. There is also an additive risk of neuroleptic malignant syndrome and blood pressure changes. The combination is used in practice but requires vigilance.
What this interaction means in plain words
Aripiprazole and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Pharmacodynamic overlap: MAO inhibition increases monoamines while aripiprazole modulates dopamine and serotonin receptors.
What to do
Monitor for agitation, tremor, hyperthermia, rigidity and autonomic instability, especially at initiation and dose changes. Stop the agents if serotonin syndrome or NMS is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Tranylcypromine?
MediHelp rates the interaction as moderate. Aripiprazole and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an MAO inhibitor with aripiprazole can occasionally cause serotonin toxicity because aripiprazole has serotonergic receptor activity. There is also an additive risk of neuroleptic malignant syndrome and blood pressure changes. The combination is used in practice but requires vigilance.
How serious is the interaction between Aripiprazole and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, rigidity and autonomic instability, especially at initiation and dose changes. Stop the agents if serotonin syndrome or NMS is suspected.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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